Long Name A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease
Description A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease. Mitochondria are the powerhouses of our cells. Mutations in the mitochondria appear to be associated with Parkinson’s disease, a neurodegenerative disease that affects around a million people in Europe. It is triggered by the death of neurons that produce a chemical called dopamine; in order to properly work, these neurons need a lot of energy. Focusing on mitochondria dysfunction in Parkinson’s disease, the PD-MitoQUANT project aims to identify and validate molecular drivers and mechanisms of the condition and discover innovative therapeutic targets that can be further developed by the pharmaceutical companies. Current therapies can cause adverse side effects, and cannot stop, slow or reverse disease progression. This makes the improvement of Parkinson’s disease-related treatments even more urgently needed.
Objectives 1. Improve our understanding of mitochondrial dysfunction in Parkinson’s. 2. Identify and validate molecular drivers and mechanisms in Parkinson’s. 3. Discover innovative therapeutic targets that can be further progressed by the EFPIA partners in the future.
Start date 01-02-2019
End date 31-07-2022
Name Projects Type of institution Country  
Parkinson's Disease Society Of The United Kingdom LBG NEURONET PD-MitoQUANT IDEA-FAST PD-MIND Patient/carers organisation United Kingdom
Institut Du Cerveau Et De La Moelle Épinière AETIONOMY PD-MitoQUANT Academia France
Teva Pharmaceutical Industries Limited PD-MitoQUANT Mobilise-D EQIPD EPND EFPIA Israel
Centre National De La Recherche Scientifique CNRS IMPRiND PD-MitoQUANT Pharma-Cog Academia France
Consiglio Nazionale Delle Ricerche PD-MitoQUANT Academia Italy
Royal College Of Surgeons In Ireland PD-MitoQUANT Academia Ireland
University College London AMYPAD PD-MitoQUANT PHAGO EMIF Academia United Kingdom
Genexplain Gmbh PD-MitoQUANT SME Germany
Pintail Ltd PD-MitoQUANT SME Ireland
Deutsches Zentrum Fur Neurodegenerative Erkrankungen Ev IMPRiND PD-MitoQUANT PHAGO EPND Academia Germany
Stichting Katholieke Universiteit / Radboud University Nijmegen Medical Centre EPAD EQIPD PRISM AMYPAD PD-MitoQUANT PRISM2 Academia Netherlands
WP number Description Project  
WP1 Evaluation of mitochondrial dysfunction in cellular models of PD PD-MitoQUANT
WP2 Evaluation of mitochondrial dysfunction using in vivo models of PD PD-MitoQUANT
WP3 Project management and communication PD-MitoQUANT
WP4 Ethics requirements PD-MitoQUANT
Deliverable number Title Project Submission date Link Keywords  
D3.2 Dissemination and Communication Plan PD-MitoQUANT 29-04-2019
D3.3 Data management and sharing plan (DMSP) PD-MitoQUANT 31-07-2019
D3.5 Update on communication & dissemination activities PD-MitoQUANT 31-07-2020
D3.4 Data management and sharing plan (DMSP) PD-MitoQUANT 31-07-2020
Title First author last name Year Project Link Keywords  
The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells Jacoupy 2019 PD-MitoQUANT Basic science research paper, Parkinson's disease, disease mechanism, mitochondria, ubiquitinylation, in vitro
α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities Alam 2019 PD-MitoQUANT Review article, Parkinson's disease, neurobiology, chemistry, alpha-synuclein, fibrils, proteins
α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb Rey 2019 PD-MitoQUANT Alpha-synuclein, Strains, Fibrils, Prion-like spreading, Olfactory bulb
AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation Watters 2020 PD-MitoQUANT mitochondrial transport, metabolic stress, axonal injury, AMPK, lactate, microfluidic device
Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces Bendifallah 2020 PD-MitoQUANT Molecular chaperones, Protein-protein interactions, Protein-protein interfaces, Cross linking, mass spectrometry
Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs Shrivastava 2020 PD-MitoQUANT Basic research paper, protein aggregation, synucleinopathies, alpha-synuclein, Parkinson's disease
The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding Courte 2020 PD-MitoQUANT Mechanisms of disease, Parkinson's disease
The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs Landureau 2021 PD-MitoQUANT alpha-synuclein, protein misfolding, strains, limited proteolysis, hydrogen-deuterium exchange, mass spectrometry, surface mapping, neurodegenerative disease
TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition Dinh 2021 PD-MitoQUANT mice, neurons, gene, cell antibody, drosophila, rna, Parkinson
The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells Jacoupy 2019 PD-MitoQUANT
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes Scheiblich 2021 PD-MitoQUANT microglia, alpha-synuclein, tunneling nanotubes, cell-to-cell transfer, clearance, LRRK2, synucleinopathies, degradation
CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants Piazzesi 2022 PD-MitoQUANT Caenorhabditis elegans; carboxylesterase CEST-2.2; epigenetics; lipid metabolism; mitochondria.
Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation Galvagnion 2022 PD-MitoQUANT GBA; Parkinson’s disease; fibroblasts; lipidomics; α-synuclein.
SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells Jackson 2022 PD-MitoQUANT Autophagy; Caenorhabditis elegans; Longevity; MICU1; Mitochondria; Sphingosine signaling; VPS39.
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons Tourville 2022 PD-MitoQUANT 10.3390/cells11101640 α-Synuclein; cell culture model; dopamine neurons; fibril seeds; neurodegeneration; Parkinson disease; protein aggregation
AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases Wischhof 2022 PD-MitoQUANT Aapoptosis-inducing factor (AIF), CHCHD4, Mitochondria, Mitochondrial diseases, Oxidative phosphorylation (OXPHOS)
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