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Name PRISM
Long Name Psychiatric Ratings using Intermediate Stratified Markers
Description Psychiatric Ratings using Intermediate Stratified Markers. Social withdrawal is a common early symptom of many neurological disorders, including schizophrenia, Alzheimer’s disease, and major depressive disorder. However, the underlying, biological causes of this symptom are still poorly understood and may differ from one disease to another. The PRISM project will carry out a range of tests, including blood tests, brain scans, and measures of behaviour, on patients with these all too common diseases in a bid to determine which biological parameters correlate with specific clinical symptoms, like social withdrawal. The hope is that the project’s findings will shed new light on the causes of mental illness and their symptoms and facilitate the development of much-needed new treatments.
Objectives 1. To define a set of quantifiable biological parameters for social withdrawal and cognitive deficits. 2. To cluster and differentiate schizophrenia (SZ) and Alzheimer’s disease (AD) patients on the basis of quantitative biological parameters. 3. To explore dimensional relationships between pathology (e.g., cognitive deficits) and social withdrawal. 4. To develop a deeper understanding of the quantitative biology of social withdrawal using clinical data from SZ, AD and major depressive disorder (MD) patients and by establishing a network of pre-clinical research sites able to perform high quality back-translation studies. 5. To develop the regulatory path for social withdrawal across disorders.
Website https://prism-project.eu/
Start date 01-04-2016
End date 30-09-2019
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Name Projects Type of institution Country  
Janssen Pharmaceutica NV EPAD ADAPTED AMYPAD IMPRiND EQIPD NEURONET EMIF IM2PACT PHAGO PRISM RADAR-CNS RADAR-AD ROADMAP IDEA-FAST Pharma-Cog EPND EFPIA Belgium
Eli Lilly And Company Ltd EPAD IMPRiND MOPEAD PHAGO PRISM RADAR-AD ROADMAP NEURONET IDEA-FAST Pharma-Cog EFPIA United Kingdom
F. Hoffmann-La Roche AG EPAD EQIPD EMIF PHAGO PRISM ROADMAP NEURONET IDEA-FAST Pharma-Cog EPND EFPIA Switzerland
Novartis Pharma AG EPAD IMPRiND EQIPD AETIONOMY IM2PACT PRISM RADAR-AD ROADMAP Mobilise-D Pharma-Cog EPND EFPIA Switzerland
Pfizer Limited EPAD EQIPD EMIF IM2PACT PRISM Mobilise-D IDEA-FAST EFPIA United Kingdom
Stichting Katholieke Universiteit / Radboud University Nijmegen Medical Centre EPAD EQIPD PRISM AMYPAD PD-MitoQUANT PRISM2 Academia Netherlands
VU University Medical Center Amsterdam EPAD AMYPAD IM2PACT PRISM MOPEAD RADAR-CNS RADAR-AD EMIF PRISM2 Pharma-Cog EPND Academia Netherlands
Boehringer Ingelheim International Gmbh PRISM EPAD EQIPD AETIONOMY EMIF Pharma-Cog PRISM2 EFPIA Germany
Academisch Ziekenhuis Leiden PRISM IM2PACT ROADMAP IDEA-FAST PRISM2 Academia Netherlands
Alma Mater Studiorum - Universita Di Bologna PRISM Mobilise-D PRISM2 Academia Italy
Consorcio Centro De Investigacion Biomedica En Red M.P. PRISM RADAR-CNS PRISM2 Academia Spain
Erasmus Universitair Medisch Centrum Rotterdam PRISM ADAPTED AETIONOMY EMIF ROADMAP EPAD IDEA-FAST Academia Netherlands
Rijksuniversiteit Groningen PRISM EQIPD ROADMAP PRISM2 Academia Netherlands
Stichting Buro Ecnp PRISM EQIPD PRISM2 Academia Netherlands
University Of Exeter PRISM EMIF PD-MIND Pharma-Cog Academia United Kingdom
Universitair Medisch Centrum Utrecht PRISM Academia Netherlands
Biotrial PRISM PRISM2 SME France
Concentris Research Management GmbH PRISM EQIPD EMIF PRISM2 SME Germany
Drug Target Id BV PRISM SME Netherlands
P1vital Limited PRISM PRISM2 SME United Kingdom
Sbgneuro LTD PRISM PRISM2 SME United Kingdom
Europese Federatie Van Familieverenigingen Van Psychiatrisch Zieke Personen Ivzw PRISM Patient/carers organisation Belgium
Takeda Pharmaceuticals International AG EPND EPAD PRISM RADAR-AD ROADMAP IDEA-FAST Mobilise-D NEURONET EFPIA Switzerland
WP number Description Project  
WP1 Consortium management and governance PRISM
WP2 Scientific consensus (clinical/pre-clinical) on study designs, instruments and methodology PRISM
WP3 Data engineering and statistics to allow integrated analysis of data sets PRISM
WP4 Clinical study implementation and operations PRISM
WP5 Clinical harmonization of experimental approaches PRISM
WP6 Pre-clinical harmonization of experimental approaches PRISM
WP7  Engagement with regulatory groups, agencies and other stakeholders PRISM
WP8 Dissemination, training and communication PRISM
Deliverable number Title Project Submission date Link Keywords  
D6.5 Social withdrawal SOP disseminated to WP6 partners and workshop held PRISM 22-09-2017 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5bb2331de&appId=PPGMS
D2.1 Consensus framework document on selection of tools and instruments, and inclusion/exclusion criteria for clinical deep phenotyping PRISM 28-06-2016 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5bcc61a3c&appId=PPGMS
D7.4 Report by the Scientific and Ethics Advisory Board (SEAB), in consultation with the Ethics Advisor PRISM 03-04-2020 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5cde5ca26&appId=PPGMS
D2.4 Manuscript submission of review article on the selection of phenotyping methods PRISM 27-10-2017 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5bb2331dd&appId=PPGMS
D8.5 Presentation of PRISM findings to patients and their families PRISM 28-11-2019 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5cc86770d&appId=PPGMS
D5.6 Validation report on proxy indicators for cognitive deficits in patient cohorts PRISM 30-05-2019 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5c487281b&appId=PPGMS
D7.3 Consensus report on pragmatic and ecological outcomes that will increase functionality and quality of life of those affected by the disorders studies PRISM 28-01-2019 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5c0f9dc59&appId=PPGMS
D8.7 Final press release PRISM 22-10-2019 https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5cc87a5dd&appId=PPGMS
Title First author last name Year Project Link Keywords  
Autism spectrum disorders and autistic traits share genetics and biology. Molecular Psychiatry. Bralten 2017 PRISM https://doi.org/10.1038/mp.2017.98 Clinical research paper, Autism, ASD, GWAS, genetic
Social functioning in patients with depressive and anxiety disorders Saris 2017 PRISM https://doi.org/10.1111/acps.12774 Psychosocial research paper, clinical research, depression, anxiety, social functioning
The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies Harari 2017 PRISM https://doi.org/10.1038/s41537-017-0036-2 Systematic review, schizophrenia, psychotic disorders, MRI, GWAS
A quantitative approach to neuropsychiatry: The why and the how Kas 2019 PRISM https://doi.org/10.1016/j.neubiorev.2017.12.008 Review article, Schizophrenia, Alzheimer’s Disease, Major Depression, Behaviour, EEG, Neuro-imaging, Genetics, Smartphone technology, Mouse, Human, Cross-disorder, Transdiagnostic, Drug discovery, Translational research, Sensory processing, Social withdrawal, Attention, Working memory, Quantitative biology
The Visible Burrow System: A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains. Bove 2018 PRISM https://doi.org/10.1016/j.bbr.2018.02.003 Basic science research paper, Visible burrow system, BTBR mice, C57BL/6J mice, Sociability, Social withdrawal
Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum Hornix 2018 PRISM https://doi.org/10.1016/j.neubiorev.2018.02.010 Review article, Sensory processing, Neurodevelopment, Multisensory integration, Synaptic plasticity, Therapeutic windows, Neuropsychiatric disorders, Schizophrenia, Autism spectrum disorder, Genetics, Neural circuits
Genetic underpinnings of sociability in the UK Biobank Bralten 2019 PRISM https://doi.org/10.1101/781195 Clinical research paper, preprint, neuropsychiatric disorders, Alzheimer's disease, early manifestation, risk factor, GWAS
RFID-supported video tracking for automated analysis of social behaviour in groups of mice Peleh 2019 PRISM https://doi.org/10.1016/j.jneumeth.2019.108323 Basic science research paper, Methodology, Automated, Mouse tracking, Social behaviour, Video tracking, RFID
Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia Winsky-Sommerer 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.09.027 Review article, Amyloid clearance Animal models, Apathy, Circadian, Cognition, PRISM, REM sleep, Sleep fragmentation, Social withdrawal, Spindles, rTg4510, Transgenic models,
Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer’s disease Bilderbeck 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.06.019 Clinical study protocol, Schizophrenia, Alzheimer’s disease, Social withdrawal, Cognition, MRI, EEG, RDOC
Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer’s disease van der Wee 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.06.020 Review article, Social withdrawal, PRISM, Subjective and objective assessments, Neurobiological and behavioral paradigms in schizophrenia, Alzheimer and depression, MRI, EEG, Passive remote monitoring, Digital phenotyping
Social brain, social dysfunction and social withdrawal Porcelli 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.09.012 Review article, Social withdrawal, Neurobiology, Social brain, Social dysfunction, Social impairments, Social cognition, Social functioning, Schizophrenia, Alzheimer’s disease, Major depression disorder
Quantitative neurosymptomatics: Linking quantitative biology to neuropsychiatry Kas 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.11.013 Editorial, neuropsychiatry, mechanisms, biology
The PRISM project: social withdrawal from an RDoC perspective Cuthbert 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.08.006 Review article, Social withdrawal, Psychiatric diagnosis, Psychiatric nosology, Research domain criteria, RDoC
Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection Gilmour 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.09.025 Review article, Alzheimer’s Disease, schizophrenia, working memory, translation, social withdrawal
Electrophysiological assessment methodology of sensory processing dysfunction in schizophrenia and dementia of the Alzheimer type Danjou 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.09.004 Review article, Schizophrenia, Alzheimer’s disease, Oddball paradigm, Mismatch negativity, Emotional processing, Auditory steady-state potentials, Electroencephalogram, EEG
Social withdrawal as psychopathology of mental disorders Carpenter 2019 PRISM https://doi.org/10.1016/j.neubiorev.2017.12.011 Opinion paper, social withdrawal, neuropsychiatric disorders
The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior Peleh 2019 PRISM https://doi.org/10.1016/j.neubiorev.2018.07.018 Review article, Alzheimer's disease, schizophrenia, depression, preclinical, rodent models, social behaviour
A framework for assessing neuropsychiatric phenotypes by using smartphone-based location data Jongs 2020 PRISM https://doi.org/10.1038/s41398-020-00893-4 Neuroscience, Biomarkers
Negative Symptoms in Early-Onset Psychosis and Their Association With Antipsychotic Treatment Failure Downs 2019 PRISM https://pubmed.ncbi.nlm.nih.gov/29370404/ Early-onset psychosis, first-episode psychosis, negative symptoms, antipsychotic agents, treatment resistance
Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders Díaz-Caneja 2019 PRISM https://dx.doi.org/10.1002%2Fhbm.24475 MRI, autism spectrum disorder, cortical surface area, cortical thickness, first-episode psychosis, neurodevelopment.
Characterisation of the clinical phenotype in Phelan-McDermid syndrome Burdeus-Olavarrieta 2021 PRISM https://doi.org/10.1186/s11689-021-09370-5 Phelan-McDermid syndrome, 22q13 deletion syndrome, SHANK3, Intellectual disability, Autism
Social Dysfunction is Transdiagnostically Associated with Default Mode Network Dysconnectivity in Schizophrenia and Alzheimer’s Disease Saris 2021 PRISM https://doi.org/10.1080/15622975.2021.1966714 Social Dysfunction, DMN, Schizophrenia, Alzheimer’s, Transdiagnostic
Effect of disease related biases on the subjective assessment of social functioning in Alzheimer's disease and schizophrenia patients Jongs 2022 PRISM https://doi.org/10.1016/j.jpsychires.2020.11.013 Alzheimer Disease* / complications Alzheimer Disease, psychology, Bias, Caregivers, psychology, Humans, Schizophrenia, complications, Social Interaction,
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